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KMID : 0369819810110030314
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Jorunal of Korean Pharmaceutical Sciences
1981 Volume.11 No. 3 p.314 ~ p.320
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Study on the Design of Contraceptive Agent (Ⅰ)
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김성호/Kim SH
최준식/백채선/Choi JS/Baik CS
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Abstract
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One of the major objectives in the developments of a progesterone I.U.D. is to prepare devices which release drug at a constant rate for extended periods. A constant release rate is achived by maintaining drug concentration at a constant valve via the introduction of rate limiting membrane to solute diffusion at the surface of the devices. In this study, progesterone dispersed at monolithic device were prepared from polyhydroxy ethyl methacrylate. Constant release rate were obtained with device which were soaked in on ethanol-hexan solution. The release rate was dependant upon the concentration of the ethanolic solution in the soaking solution. This devices offer significant potential for futher development of hydrogel in the intrauterine contraception device for controlled release of progesterone.
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